Affordable Access

Disease-modifying therapies in multiple sclerosis: an update on recent and ongoing trials and future strategies.

Authors
  • Wiendl, Heinz
  • Kieseier, Bernd C
Type
Published Article
Journal
Expert opinion on investigational drugs
Publication Date
Apr 01, 2003
Volume
12
Issue
4
Pages
689–712
Identifiers
PMID: 12665424
Source
Medline
License
Unknown

Abstract

Multiple sclerosis (MS) is the prototype inflammatory autoimmune disorder of the central nervous system and the most common cause of neurological disability in young adults exhibiting considerable clinical, radiological and pathological heterogeneity. Novel insights in the immunopathological processes, advances in biotechnology, development of powerful magnetic resonance imaging technologies together with improvements in clinical trial design led to a variety of evaluable therapeutic approaches. Therapy has changed dramatically over the past decade, yielding significant progress for the treatment of relapsing-remitting and secondary progressive MS. A substantial number of pivotal and preliminary reports continue to demonstrate encouraging new evidence that advances are being made in the care of MS patients. This review summarises recent progress with currently available disease-modifying therapies and - on the basis of present immunopathogenetic concepts - outlines ongoing studies as well as future treatment strategies.

Report this publication

Statistics

Seen <100 times