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Disease Manifestation and Viral Sequences in a Bonobo More Than 30 Years after Papillomavirus Infection

Authors
  • Hoffmann, Markus1
  • Schütze, Enrika2
  • Bernhard, Andreas
  • Schlaphoff, Lennart1
  • Kaul, Artur1
  • Schöniger, Sandra2
  • Pöhlmann, Stefan1, 3
  • 1 (A.K.)
  • 2 (S.S.)
  • 3 Faculty of Biology and Psychology, University of Göttingen, 37073 Göttingen, Germany
Type
Published Article
Journal
Pathogens
Publisher
MDPI
Publication Date
Jan 26, 2019
Volume
8
Issue
1
Identifiers
DOI: 10.3390/pathogens8010013
PMID: 30691118
PMCID: PMC6470980
Source
PubMed Central
Keywords
License
Green

Abstract

Pan paniscus Papillomavirus 1 (PpPV1) causes focal epithelial hyperplasia (FEH) in infected animals. Here, we analyzed the present disease manifestation and PpPV1 genomic sequence of an animal that was afflicted by an FEH epizootic outbreak in 1987 for which the sequence of the responsible PpPV1 was determined. The animal displayed FEH more than 30 years after the initial diagnosis, indicating persistence or recurrence of the disease, and evidence for active PpPV1 infection was obtained. Moreover, the sequences of the viral genomes present in the late 1980s and in 2018 differed at 23 nucleotide positions, resulting in 11 amino acid exchanges within coding regions. These findings suggest that PpPV1-induced FEH might not undergo complete and/or permanent remission in a subset of afflicted animals.

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