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Discriminative stimulus functions in rats of AM1346, a high-affinity CB1R selective anandamide analog.

Authors
  • Järbe, Torbjörn U C
  • Li, Chen
  • Liu, Qian
  • Makriyannis, Alexandros
Type
Published Article
Journal
Psychopharmacology
Publication Date
Apr 01, 2009
Volume
203
Issue
2
Pages
229–239
Identifiers
DOI: 10.1007/s00213-008-1199-3
PMID: 18521574
Source
Medline
License
Unknown

Abstract

Unlike mAEA, the surmountable antagonism between rimonabant and AM1346 showed that the structural features of AEA can be modified to produce novel ligands that reduce the dissociation between the discriminative stimulus and rate decreasing effects of CB(1)R agonists derived from an AEA template.

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