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Discrepant effects of inducible nitric oxide synthase modulation on systemic and splanchnic endothelial nitric oxide synthase activity and expression in cirrhotic rats.

Authors
Type
Published Article
Journal
Journal of gastroenterology and hepatology
Publication Date
Volume
22
Issue
12
Pages
2195–2201
Identifiers
PMID: 18031380
Source
Medline
License
Unknown

Abstract

The results of this study may explain the worsening of the hyperdynamic state in cirrhosis during septic shock by direct LPS-induced eNOS activation in large systemic vessels, and its inhibition in concomitant small splanchnic vasculature by iNOS synthesized NO.

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