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Discrepant effects of inducible nitric oxide synthase modulation on systemic and splanchnic endothelial nitric oxide synthase activity and expression in cirrhotic rats.

Authors
  • Malyshev, Eugene
  • Tazi, Khalid A
  • Moreau, Richard
  • Lebrec, Didier
Type
Published Article
Journal
Journal of gastroenterology and hepatology
Publication Date
Dec 01, 2007
Volume
22
Issue
12
Pages
2195–2201
Identifiers
PMID: 18031380
Source
Medline
License
Unknown

Abstract

The results of this study may explain the worsening of the hyperdynamic state in cirrhosis during septic shock by direct LPS-induced eNOS activation in large systemic vessels, and its inhibition in concomitant small splanchnic vasculature by iNOS synthesized NO.

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