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Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection.

  • Reynolds, CJ
  • Swadling, L
  • Gibbons, JM
  • Pade, C
  • Jensen, MP
  • Diniz, MO
  • Schmidt, NM
  • Butler, DK
  • Amin, OE
  • Bailey, SNL
  • Murray, SM
  • Pieper, FP
  • Taylor, S
  • Jones, J
  • Jones, M
  • Lee, W-YJ
  • Rosenheim, J
  • Chandran, A
  • Joy, G
  • Di Genova, C
  • And 20 more
Publication Date
Dec 18, 2020
UPCommons. Portal del coneixement obert de la UPC
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Understanding the nature of immunity following mild/asymptomatic infection with SARS-CoV-2 is crucial to controlling the pandemic. We analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 weeks after United Kingdom lockdown, 76 of whom had mild/asymptomatic SARS-CoV-2 infection captured by serial sampling. Neutralizing antibodies (nAb) were present in 89% of previously infected HCW. T cell responses tended to be lower following asymptomatic infection than in those reporting case-definition symptoms of COVID-19, while nAb titers were maintained irrespective of symptoms. T cell and antibody responses were sometimes discordant. Eleven percent lacked nAb and had undetectable T cell responses to spike protein but had T cells reactive with other SARS-CoV-2 antigens. Our findings suggest that the majority of individuals with mild or asymptomatic SARS-CoV-2 infection carry nAb complemented by multispecific T cell responses at 16-18 weeks after mild or asymptomatic SARS-CoV-2 infection.

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