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Directional local field potentials: A tool to optimize deep brain stimulation

  • Tinkhauser, Gerd
  • Pogosyan, Alek
  • Debove, Ines
  • Nowacki, Andreas
  • Shah, Syed Ahmar
  • Seidel, Kathleen
  • Tan, Huiling
  • Brittain, John-Stuart
  • Petermann, Katrin
  • di Biase, Lazzaro
  • Oertel, Markus F
  • Pollo, Claudio
  • Brown, Peter
  • Schuepbach, Michael
Publication Date
Nov 18, 2018
Zurich Open Repository and Archive
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Background: Although recently introduced directional DBS leads provide control of the stimulation field, pro- graming is time-consuming. Objectives: Here, we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with PD. Methods: Intraoperative local field potentials were recorded from directional contacts in the STN of 12 patients and beta activity compared with the results of the clinical contact review performed after 4 to 7 months. Results: Normalized beta activity was positively corre- lated with the contact’s clinical efficacy. The two con- tacts with the highest beta activity included the most efficient stimulation contact in up to 92% and that with the widest therapeutic window in 74% of cases. Conclusion: Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional DBS. V C 2017 The Authors. Movement Disor- ders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. Key Words: Parkinson’s disease; deep brain stimula- tion; directional leads; local field potentials; DBS programming

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