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Direction selectivity in retinal bipolar cell axon terminals

Authors
  • Matsumoto, Akihiro1
  • Agbariah, Weaam2
  • Nolte, Stella Solveig1
  • Andrawos, Rawan2
  • Levi, Hadara2
  • Sabbah, Shai2
  • Yonehara, Keisuke1
  • 1 Danish Research Institute of Translational Neuroscience – DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Department of Biomedicine, Aarhus University, Ole Worms Allé 8, 8000 Aarhus C, Denmark
  • 2 Department of Medical Neurobiology, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel
Type
Published Article
Journal
Neuron
Publisher
Cell Press
Publication Date
Sep 15, 2021
Volume
109
Issue
18
Pages
2928–2942
Identifiers
DOI: 10.1016/j.neuron.2021.07.008
PMID: 34390651
PMCID: PMC8478419
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

Matsumoto et al. uncover that cardinal direction selectivity emerges in retinal bipolar cell axon terminals. The selectivity is established de novo at the terminals by starburst amacrine cells, mediated by both cholinergic transmission and wide-field amacrine cells. The bipolar cells transmit tuned glutamate inputs to directional preference-matched ganglion cells.

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