Affordable Access

deepdyve-link
Publisher Website

Higher postoperative plasma EV PD-L1 predicts poor survival in patients with gastric cancer.

Authors
  • Li, Gaopeng1
  • Wang, Guoliang2
  • Chi, Fenqing3
  • Jia, Yuqi3
  • Wang, Xi3
  • Mu, Quankai3
  • Qin, Keru3
  • Zhu, Xiaoxia3
  • Pang, Jing3
  • Xu, Baixue3
  • Feng, Guangen3
  • Niu, Yuhu3
  • Gong, Tao3
  • Zhang, Hongwei4
  • Dong, Xiushan5
  • Liu, Ting6
  • Ma, Jinfeng6
  • Gao, Zefeng6
  • Tao, Kai7
  • Li, Feng8
  • And 2 more
  • 1 Department of hepatobiliary surgery, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Tongji Medical College, Huazhong University of Science and Technology, Taiyuan, China. , (China)
  • 2 Laboratory of Tumor and Immunology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, China. , (China)
  • 3 Department of Biochemistry and Molecular Biology, School of Basic Medicine, Shanxi Key Laboratory of Birth Defects and Cell Regeneration, Key Laboratory of Cellular Physiology (Shanxi Medical University) of Ministry of Education, Shanxi Medical University, Taiyuan, China. , (China)
  • 4 Department of Haematology, Shanxi Cancer Hospital of Shanxi Medical University, Taiyuan, China. , (China)
  • 5 Department of General Surgery, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Tongji Medical College, Huazhong University of Science and Technology, Taiyuan, China. , (China)
  • 6 Department of General Surgery, Shanxi Cancer Hospital of Shanxi Medical University, Taiyuan, China. , (China)
  • 7 Department of Minimal Invasive Digestive Surgery, Shanxi Cancer Hospital of Shanxi Medical University, Taiyuan, China. , (China)
  • 8 Department of Molecular Biology, Shanxi Cancer Hospital of Shanxi Medical University, Taiyuan, China. , (China)
  • 9 Department of General Surgery, First Hospital of Shanxi Medical University, Taiyuan, China [email protected] [email protected] , (China)
  • 10 Department of Biochemistry and Molecular Biology, School of Basic Medicine, Shanxi Key Laboratory of Birth Defects and Cell Regeneration, Key Laboratory of Cellular Physiology (Shanxi Medical University) of Ministry of Education, Shanxi Medical University, Taiyuan, China [email protected] [email protected] , (China)
Type
Published Article
Journal
Journal for ImmunoTherapy of Cancer
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Mar 01, 2021
Volume
9
Issue
3
Identifiers
DOI: 10.1136/jitc-2020-002218
PMID: 33753568
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The satisfactory prognostic indicator of gastric cancer (GC) patients after surgery is still lacking. Perioperative plasma extracellular vesicular programmed cell death ligand-1 (ePD-L1) has been demonstrated as a potential prognosis biomarker in many types of cancers. The prognostic value of postoperative plasma ePD-L1 has not been characterized. We evaluated the prognostic value of preoperative, postoperative and change in plasma ePD-L1, as well as plasma soluble PD-L1, in short-term survival of GC patients after surgery. The Kaplan-Meier survival model and Cox proportional hazards models for both univariate and multivariate analyzes were used. And the comparison between postoperative ePD-L1 and conventional serum biomarkers (carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9) and CA72-4) in prognostic of GC patients was made. The prognostic value of postoperative ePD-L1 is superior to that of preoperative ePD-L1 on GC patients after resection, and also superior to that of conventional serum biomarkers (CEA, CA19-9 and CA72-4). The levels of postoperative ePD-L1 and ePD-L1 change are independent prognostic factors for overall survival and recurrence free survival of GC patients. High plasma level of postoperative ePD-L1 correlates significantly with poor survival, while high change in ePD-L1 level brings the significant survival benefit. The level of plasma postoperative ePD-L1 could be considered as a candidate prognostic biomarker of GC patients after resection. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Report this publication

Statistics

Seen <100 times