Direct synthesis of pyrroles from imines, alkynes, and acid chlorides: an isocyanide-mediated reaction.
- Published Article
American Chemical Society
- Publication Date
Feb 01, 2007
[reaction: see text] A direct synthesis of pyrroles from imines, acid chlorides, and alkynes mediated by isocyanides is reported. This reaction proceeds with a range of each of these three substrates, providing a method to generate families of pyrroles in high yield. Mechanistic studies suggest this process proceeds via the generation of imino analogues of munchnones, which can undergo in situ coupling with alkynes to liberate isocyanate and form the pyrrole product.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/17249784