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Direct Measurement of the Anti-Influenza Agent Zanamivir in the Respiratory Tract following Inhalation

Authors
  • Amy W. Peng
  • Stefano Milleri
  • Daniel S. Stein
Publisher
American Society for Microbiology
Publication Date
Jul 01, 2000
Source
PMC
Keywords
License
Unknown

Abstract

In a single-center, randomized study, zanamivir (Relenza) concentrations in induced sputum samples and nasal washings of healthy adults following oral inhalation were measured. Concentrations in sputum exceeded the median viral neuraminidase 50% inhibitory concentration at 6, 12, and 24 h, and those in nasal washings did so at 6 and 12 h. There were no zanamivir-related adverse events or laboratory abnormalities.

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