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Direct inhibitory mechanisms of halothane on human platelet aggregation.

Authors
Type
Published Article
Journal
Anesthesiology
Publication Date
Volume
85
Issue
1
Identifiers
PMID: 8694388
Source
Medline

Abstract

Halothane inhibits thrombin-induced human platelet aggregation by decreasing [Ca2+]i without inhibiting agonist-receptor binding; the inhibitory effect of halothane on [Ca2+]i might be mediated by a decrease in inositol 1,4,5 triphosphate and in part by an increase in [cAMP]i.

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