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Direct inhibitory effect of fluoxetine on N-methyl-D-aspartate receptors in the central nervous system.

Authors
  • Szasz, Bernadett K1
  • Mike, Arpad
  • Karoly, Robert
  • Gerevich, Zoltan
  • Illes, Peter
  • Vizi, E Sylvester
  • Kiss, Janos P
  • 1 Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u.43, Budapest, Hungary. , (Hungary)
Type
Published Article
Journal
Biological Psychiatry
Publisher
Elsevier
Publication Date
Dec 01, 2007
Volume
62
Issue
11
Pages
1303–1309
Identifiers
PMID: 17659262
Source
Medline
License
Unknown

Abstract

The fact that different classes of antidepressants were found to be low-affinity NMDA antagonists suggests that direct inhibition of NMDA receptors may contribute to the clinical effects of antidepressants.

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