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Direct or indirect regulation of muscle protein synthesis by energy status?

Authors
  • Moinard, Christophe1
  • Fontaine, Eric2
  • 1 Univ. Grenoble Alpes, LBFA et BEeSy, INSERM U1055, Grenoble, France. Electronic address: [email protected] , (France)
  • 2 Univ. Grenoble Alpes, LBFA et BEeSy, INSERM U1055, Grenoble, France. , (France)
Type
Published Article
Journal
Clinical nutrition (Edinburgh, Scotland)
Publication Date
Apr 01, 2021
Volume
40
Issue
4
Pages
1893–1896
Identifiers
DOI: 10.1016/j.clnu.2020.07.015
PMID: 32788089
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Muscle protein synthesis (MPS) is a complex and finely-regulated mechanism that plays a key role in muscle homeostasis. Amino acid bioavailability is widely considered a major driver of MPS regulation via mTOR pathway activation. However, recent results suggest that amino acid bioavailability affects cellular energy status. Whatever the tool used to modulate energy status (amino acid depletion or mild mitochondrial uncoupling), a decrease in cellular energy status decreases MPS, without necessarily involving the mTOR pathway. Here we propose that energy status directly regulates one or several energy-consuming step(s) during MPS. This new paradigm modifies our vision of protein metabolism and raises prospects for new advances in therapeutics. Copyright © 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

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