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Direct evidence for the ongoing brain activation by enhanced dynorphinergic system in the spinal cord under inflammatory noxious stimuli.

Authors
  • Taketa, Yasuko
  • Niikura, Keiichi
  • Kobayashi, Yasuhisa
  • Furuya, Masaharu
  • Shimizu, Toshikazu
  • Narita, Michiko
  • Imai, Satoshi
  • Kuzumaki, Naoko
  • Maitani, Yoshie
  • Yamazaki, Mitsuaki
  • Inada, Eiichi
  • Iseki, Masako
  • Suzuki, Tsutomu
  • Narita, Minoru
Type
Published Article
Journal
Anesthesiology
Publication Date
Feb 01, 2010
Volume
112
Issue
2
Pages
418–431
Identifiers
DOI: 10.1097/ALN.0b013e3181ca31d9
PMID: 20068450
Source
Medline
License
Unknown

Abstract

These findings indicate that spinally released dynorphin A (1-17) by noxious stimuli leads to the direct activation of ascending pain transmission.

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