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Direct comparison of radiation dosimetry of six PET tracers using human whole-body imaging and murine biodistribution studies.

Authors
  • Sakata, Muneyuki1
  • Oda, Keiichi
  • Toyohara, Jun
  • Ishii, Kenji
  • Nariai, Tadashi
  • Ishiwata, Kiichi
  • 1 Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1-1 Naka-cho, Itabashi-ku, Tokyo 173-0022, Japan. [email protected] , (Japan)
Type
Published Article
Journal
Annals of Nuclear Medicine
Publisher
Springer-Verlag
Publication Date
Apr 01, 2013
Volume
27
Issue
3
Pages
285–296
Identifiers
DOI: 10.1007/s12149-013-0685-9
PMID: 23404061
Source
Medline
License
Unknown

Abstract

Although the mouse-derived effective doses were roughly comparable to the human-derived doses in most cases, considerable differences were found for critical organ dose estimates and pharmacokinetics in certain cases. Whole-body imaging for investigation of radiation dosimetry is desirable for the initial clinical evaluation of new PET probes prior to their application in subsequent clinical investigations.

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