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Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes

Authors
  • Wong, Marie L. J.1
  • Sterling, Alistair J.1
  • Mousseau, James J.2
  • Duarte, Fernanda1
  • Anderson, Edward A.1
  • 1 Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK , Oxford (United Kingdom)
  • 2 Pfizer Medicine Design, Eastern Point Road, Groton, CT 06340, USA , Groton (United States)
Type
Published Article
Journal
Nature Communications
Publisher
Springer Nature
Publication Date
Mar 12, 2021
Volume
12
Issue
1
Identifiers
DOI: 10.1038/s41467-021-21936-4
Source
Springer Nature
License
Green

Abstract

Bicyclo[1.1.1]pentanes (BCPs) are important motifs in contemporary drug design, however, approaches to BCPs featuring adjacent stereocenters are rather limited. Here, the authors report a photo- and organocatalyzed asymmetric addition of simple aldehydes to [1.1.1]propellane to generate enantioenriched α-chiral BCPs.

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