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[Diphasic action of apomorphine on motility in the rat. II. Time aspects of the effect of a single dose].

Authors
  • Vaccheri, A
  • Gandolfi, O
  • Dall'Olio, R
  • Montanaro, N
Type
Published Article
Journal
Bollettino della Società italiana di biologia sperimentale
Publication Date
Feb 28, 1981
Volume
57
Issue
4
Pages
381–386
Identifiers
PMID: 7236418
Source
Medline
License
Unknown

Abstract

The locomotor activity of rats subcutaneously treated with apomorphine HCl (300 microgram/kg, 30 sec before emmission into actometers) was evaluated every 60 sec for 1 hour. An inhibitory phase appeared in the first 6 min of recording in comparison to the more elevated values of the control group. From 18th to 44th min a more sustained activity was easily recognizable in treated rats in comparison to the decline of control values. The results were discussed by supposing that the first amounts of drug entering CNS stimulated pre-synaptic dopamine receptors and the full dose activated post-synaptic dopamine neurons. The study of time-course of a single dose of apomorphine could be a useful model for evaluating pre- and post-synaptic effects of antidopaminergic drugs.

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