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Dipeptide monoester ganciclovir prodrugs for treating HSV-1-induced corneal epithelial and stromal keratitis: in vitro and in vivo evaluations.

Authors
  • Majumdar, Soumyajit
  • Nashed, Yasser E
  • Patel, Kunal
  • Jain, Ritesh
  • Itahashi, Motoki
  • Neumann, Donna M
  • Hill, James M
  • Mitra, Ashim K
Type
Published Article
Journal
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Publication Date
Dec 01, 2005
Volume
21
Issue
6
Pages
463–474
Identifiers
PMID: 16386088
Source
Medline
License
Unknown

Abstract

Val-Val-GCV demonstrates excellent corneal permeability and chemical stability, high aqueous solubility, and substantial in vivo antiviral activity against the HSV-1.

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