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Dimethylarginine dimethylaminohydrolase inhibition and asymmetric dimethylarginine accumulation contribute to endothelial dysfunction in rats exposed to glycosylated protein: effects of aminoguanidine.

Authors
  • Yin, Qing-Feng1
  • Fu, Si-Hai
  • He, Pei
  • Xiong, Yan
  • 1 Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, Hunan, PR China. , (China)
Type
Published Article
Journal
Atherosclerosis
Publisher
Elsevier
Publication Date
Jan 01, 2007
Volume
190
Issue
1
Pages
53–61
Identifiers
PMID: 16533509
Source
Medline
License
Unknown

Abstract

Decreased DDAH activity and elevated endogenous ADMA is implicated in endothelial dysfunction of rats exposed to GBSA. Aminoguanidine can protect endothelium of rat aorta against injury induced by GBSA both in vitro and in vivo.

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