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Dilantin-calcium interaction and active Na transport in frog skin.

Authors
  • Riddle, T G
  • Mandel, L J
  • Goldner, M M
Type
Published Article
Journal
European Journal of Pharmacology
Publisher
Elsevier
Publication Date
Aug 01, 1975
Volume
33
Issue
1
Pages
189–192
Identifiers
PMID: 1080708
Source
Medline
License
Unknown

Abstract

The effects of diphenylhydantoin (DPH) and calcium were simultaneously studied on solute transport in frog skin. In the presence of external Ca, DPH elicited a significant increase in active Na transport; in its absence, DPH had no significant effect on active transport. DPH increased passive permeability, but this action was independent of Ca. It appears that the increase in active transport elicited by DPH is due to a specific interaction with Ca at the transport site.

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