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Digital orbitoplethysmograph: A new device to study the regional cerebral circulation using extraorbital plethysmography.

Authors
  • Bezrouk, Aleš1
  • Hosszú, Tomáš2
  • Falzon, Owen3
  • Voda, Petr4
  • Vachek, Mikuláš2
  • Záhora, Jiří4
  • Mašín, Vladimír4
  • Camilleri, Kenneth P5
  • Kremláček, Jan6
  • 1 Department of Medical Biophysics, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic. Electronic address: [email protected] , (Czechia)
  • 2 Department of Neurosurgery, University hospital Hradec Kralove, Hradec Kralove, Czech Republic. , (Czechia)
  • 3 Centre for Biomedical Cybernetics, University of Malta, Msida, Malta. , (Malta)
  • 4 Department of Medical Biophysics, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic. , (Czechia)
  • 5 Department of Systems & Control Engineering, Faculty of Engineering, University of Malta, Msida, Malta. , (Malta)
  • 6 Department of Pathological Physiology, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic. , (Czechia)
Type
Published Article
Journal
Journal of neuroscience methods
Publication Date
Oct 12, 2019
Volume
329
Pages
108459–108459
Identifiers
DOI: 10.1016/j.jneumeth.2019.108459
PMID: 31614161
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Noninvasive diagnostic methods utilizing pulse wave measurements on the surface of the head are an important tool in diagnosing various types of cerebrovascular disease. The measurement of extraorbital pressure fluctuations reflects intraocular and intracranial pressure changes and can be used to estimate pressure changes in intracranial arteries and the collateral circulation. In this paper, we describe our patented (CZ 305757) digital device for noninvasive measuring and monitoring of orbital movements using pressure detection. We conducted preclinical tests (126 measurements on 42 volunteers) to evaluate the practical capabilities of our device. Two human experts visually assessed the quality of the pressure pulsation and discriminability among various test conditions (specifically, subject lying, sitting, and the Matas carotid occlusion test). The results showed that our device provided clinically relevant outcomes with a sufficient level of detail of the pulse wave and a high reliability (not less than 85%) in all clinically relevant situations. It was possible to record the effect of the Matas carotid occlusion test. Our fully noninvasive, lightweight (185 g), portable, and wireless device provides a considerably cheaper alternative to the current diagnostic methods (e.g., transcranial ultrasound, X-ray, or MRI angiography) for specific assessment of cerebral circulation. Within a minute, it can detect the Willis circle integrity and thus eliminate the potential risks associated with the Matas test using standard EEG. Our device represents an improvement and a valid alternative to the current methods diagnosing regional cerebral circulation. Copyright © 2019 Elsevier B.V. All rights reserved.

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