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Diffusive searches in high-dimensional spaces and apparent 'two-state' behaviour in protein folding.

Authors
  • McLeish, T C B
Type
Published Article
Journal
Journal of physics. Condensed matter : an Institute of Physics journal
Publication Date
Feb 15, 2006
Volume
18
Issue
6
Pages
1861–1868
Identifiers
DOI: 10.1088/0953-8984/18/6/003
PMID: 21697560
Source
Medline
License
Unknown

Abstract

We extend a simple model for protein folding as a high-dimensional diffusive search. By solving a steady-state diffusion equation on a hypersphere centred on an absorbing 'native state' we find the general property that the kinetics of such a search will always be nearly single exponential. This explains the common observation of such simple 'two-state' folding kinetics in models that contain considerable intermediate structure. It also suggests that the experimental signature of single-exponential folding kinetics does not imply a simple two-state structure to the folding space.

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