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Diffusional and compartmental models for tracer washout records of Na in dog carotid.

Authors
  • Smith, G A
  • Madden, J A
  • Llaurado, J G
Type
Published Article
Journal
International journal of bio-medical computing
Publication Date
Jul 01, 1982
Volume
13
Issue
4
Pages
279–302
Identifiers
PMID: 7129663
Source
Medline
License
Unknown

Abstract

This paper re-examines studies of Na kinetics in canine carotid arterial wall previously reported by three groups of investigators. The similarities and differences in experimental and analytical approaches for Na arterial wall washout therein are reviewed. Major conclusions are: (1) A three-compartment model in series is adequate for all short and long (after subtracting the small slow exponential) records. (2) Values for the diffusion coefficient, however, varied markedly among the different groups. (3) A continuous sampling method as opposed to an intermittent one measures better the kinetics of a rapidly exchanging ion as Na+. (4) Models based on individual washout records are better than those based on ensemble averaging. Characterization of sets of results in terms of mean values for comparing parameters provides significant potential for distinguishing quantitative features between control and treated sets despite inadequacies in data sampling or model specifications.

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