Affordable Access

deepdyve-link
Publisher Website

Diffusion Tensor Imaging: Tool for Tracking Injured Spinal Cord Fibres in Rat.

Authors
  • Murgoci, Adriana-Natalia1
  • Baciak, Ladislav2
  • Cubinkova, Veronika1
  • Smolek, Tomas1
  • Tvrdik, Tomas2
  • Juranek, Ivo3
  • Kafka, Jozef4
  • Cizkova, Dasa5, 6
  • 1 Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská cesta 9, 845 10, Bratislava, Slovakia. , (Slovakia)
  • 2 Central Laboratories, Slovak University of Technology, 812 37, Bratislava, Slovakia. , (Slovakia)
  • 3 Institute of Experimental Pharmacology and Toxicology, CEM of the SAS, 841 04, Bratislava, Slovakia. , (Slovakia)
  • 4 Department of Anatomy, Histology and Physiology, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, Kosice, 041 81, Slovakia. , (Slovakia)
  • 5 Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská cesta 9, 845 10, Bratislava, Slovakia. [email protected] , (Slovakia)
  • 6 Department of Anatomy, Histology and Physiology, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, Kosice, 041 81, Slovakia. [email protected] , (Slovakia)
Type
Published Article
Journal
Neurochemical Research
Publisher
Springer-Verlag
Publication Date
Jan 01, 2020
Volume
45
Issue
1
Pages
180–187
Identifiers
DOI: 10.1007/s11064-019-02801-9
PMID: 31055738
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Spinal cord injury (SCI) is a severe disorder of the CNS leading to tissue damage and disability. Because it is critical to understand the pathological processes, it is important to find efficient ways to diagnose the severity of injured spinal cord tracts in situ from beginning up to a certain level of recovery following therapeutic interventions. In the current study, we set-up the criteria for diffusion tensor imaging (DTI) in order to capture changes of nerve fibre tracts in rat spinal cord compression injury. We tested four DTI parameters, such as fractional anisotropy, mean diffusivity, axial diffusivity and radial diffusivity at the lesion site, in time course of 7 weeks. Afterwards, we compared DTI data with histological results and locomotor outcomes to examine their consistency and capability of reflecting the lesion development in time. Our data confirm that DTI is a valuable in vivo imaging tool capable to distinguish damaged white matter tracts after mild SCI in rat. Fractional anisotropy showed decreased values for injury site, while the mean diffusivity had higher values, with increased both axial and radial diffusivity in comparison to control subjects. Thus, the combination of DTI parameters can reflect the severity of lesion in time and may correlate with histological evaluation of spared tissue, but not with locomotor recovery following mild injury associated with spontaneous recovery.

Report this publication

Statistics

Seen <100 times