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Diffusion model for growth factors--cell receptors interaction.

Authors
  • Despa, S I
  • Despa, F
Type
Published Article
Journal
Biosystems
Publisher
Elsevier
Publication Date
Jan 01, 1997
Volume
44
Issue
1
Pages
59–68
Identifiers
PMID: 9350357
Source
Medline
License
Unknown

Abstract

A theoretical model describing the interaction between growth factor molecules and their receptors from the cell surface within an 'off-centre' diffusion approximation is developed in this paper. It is assumed that a number of non interacting particles (growth-factor molecules) more diffusively in the presence of traps (specific receptors) which are located at the surfaces of a number of cells uniformly distributed in space. The diffusion equations system is solved by a perturbative method. The model predicts a nonlinear dependence of the receptor occupation and of the time needed to reach a threshold value of receptor occupation on the total number of cell receptors. An autocrine binding, when the ligand is secreted by the responsive cells accounts for the interaction between IL-2 and helper T-cells.

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