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Diffuse systemic sclerosis and autoimmune hepatitis: a unique association

  • RODRIGUES, Carlos Ewerton Maia
  • BORGES, Claudia Lobato
  • CARVALHO, Jozelio Freire de
Publication Date
Jan 01, 2010
Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP)
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Autoimmune hepatitis (AIH) is a chronic hepatitis of unknown etiology characterized by continuing hepatocellular necrosis and inflammation that afflicts 100,000 to 200,000 persons in the United States. It is a rare manifestation of systemic sclerosis. Only about nine reports of this association have been previously reported in the literature. Importantly, all cases had the limited clinical form of systemic. The authors describe herein the first report of a patient with diffuse systemic sclerosis who was diagnosed with AIH with positive antimitochondrial antibody and had an excellent response to immunosuppressive drugs. We also briefly review the literature regarding this issue.

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