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Diffuse pulmonary uptake on FDG-PET with normal CT diagnosed as intravascular large B-cell lymphoma: a case report and a discussion of the causes of diffuse FDG uptake in the lungs.

Authors
  • Wagner, T
  • Brechemier, D
  • Dugert, E
  • Le Guellec, S
  • Julian, A
  • Hitzel, A
  • Beyne-Rauzy, O
Type
Published Article
Journal
Cancer imaging : the official publication of the International Cancer Imaging Society
Publication Date
Jan 01, 2012
Volume
12
Pages
7–12
Identifiers
DOI: 10.1102/1470-7330.2012.0002
PMID: 22275725
Source
Medline
License
Unknown

Abstract

A 71-year-old woman was admitted to our hospital with asthenia, weight loss, fever, cognitive impairment and shortness of breath. Physical examination showed hemiparesis and cerebellar ataxia. There was no superficial lymphadenopathy. Blood tests showed raised levels of C-reactive protein and lactate dehydrogenase. Bone marrow aspiration and biopsy were negative. [18F]fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) showed intense uptake within a right apical nodule and intense and diffuse uptake of FDG in the lungs without corresponding structural CT abnormality. Lung biopsy showed intravascular large B-cell lymphoma (IVLBCL). FDG-PET findings in IVLBCL and causes of diffuse FDG lung uptake with and without CT abnormalities are discussed.

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