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Diffuse parenchymal pulmonary amyloidosis showing an objective response to bortezomib-based chemotherapy.

Authors
Type
Published Article
Journal
Internal medicine (Tokyo, Japan)
Publication Date
Volume
53
Issue
16
Pages
1809–1812
Identifiers
PMID: 25130116
Source
Medline
License
Unknown

Abstract

A 77-year-old woman was admitted because of bilateral hand numbness and dyspnea on exertion. Her serum IgG was increased, and a bone marrow aspiration analysis supported a diagnosis of multiple myeloma. Additionally, computed tomography scans of the chest showed bilateral ground glass attenuations, linear opacities, and consolidations. Transbronchial lung biopsy revealed Congo Red-positive amorphous eosinophilic deposits. She was therefore diagnosed with diffuse parenchymal pulmonary amyloidosis accompanied by multiple myeloma. Following combination chemotherapy including bortezomib, her serum monoclonal protein levels were normalized, and pulmonary function and oxygenation improved.

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