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Diffuse hypertrophy of gastric mucosa (Menétrier's disease) and iron-deficiency anaemia.

Authors
  • Singh, A K
  • Cumaraswamy, R C
  • Corrin, B
Type
Published Article
Journal
Gut
Publication Date
Sep 01, 1969
Volume
10
Issue
9
Pages
735–737
Identifiers
PMID: 5311583
Source
Medline
License
Unknown

Abstract

A 23-year-old woman presented with intractable iron-deficiency anaemia. A barium meal showed widespread mucosal abnormalities in the stomach and massive mucosal hypertrophy was found at laparotomy. Repeated tests for occult blood were negative but gastrointestinal haemorrhage was confirmed by isotopic blood labelling. In the face of persistent anaemia and radiological progression, total gastrectomy was performed, since when a normal blood picture has been maintained. The excised stomach showed hyperplasia of all the mucosal elements, minimal inflammation, and no obvious bleeding point. Blood loss was attributed to diapedesis from a greatly increased capillary network.

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