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Differing Relations to Early Atherosclerosis between Vitamin C from Supplements vs. Food in the Los Angeles Atherosclerosis Study: A Prospective Cohort Study.

Authors
  • Agarwal, Megha
  • Mehta, Puja K
  • Dwyer, James H
  • Dwyer, Kathleen M
  • Shircore, Anne M
  • Nordstrom, Cheryl K
  • Sun, Ping
  • Paul-Labrador, Maura
  • Yang, Yuching
  • Merz, C Noel Bairey
Type
Published Article
Journal
The Open Cardiovascular Medicine Journal
Publisher
Bentham Science
Publication Date
Jan 01, 2012
Volume
6
Pages
113–121
Identifiers
PMID: 23002405
Source
Medline
Keywords
License
Unknown

Abstract

Vitamin C supplementation is associated with accelerated early atherosclerosis measured by carotid IMT compared to a protective association with vitamin C from food. Theadverse association of vitamin C supplementation may be greater in patients with higher serum cholesterol levels. The current results provide a potential mechanistic understanding for the observed differences between Vitamin C in supplements vs food in prior studies. Given these observations,vitamin C supplementation does not appear to be currently advisable for prevention or treatment of atherosclerosis.

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