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Differentiation of Induced Pluripotent Stem Cells to Neural Retinal Precursor Cells on Porous Poly-Lactic-co-Glycolic Acid Scaffolds.

Authors
  • Worthington, Kristan S1, 2
  • Wiley, Luke A1
  • Guymon, C Allan2
  • Salem, Aliasger K3
  • Tucker, Budd A1
  • 1 1 Department of Ophthalmology and Visual Sciences, Wynn Institute for Vision Research, The University of Iowa , Iowa City, Iowa.
  • 2 2 Department of Chemical and Biochemical Engineering, The University of Iowa , Iowa City, Iowa.
  • 3 3 Division of Pharmaceutics and Translational Therapeutics, Department of Pharmaceutical Sciences and Experimental Therapeutics, The University of Iowa , Iowa City, Iowa.
Type
Published Article
Journal
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Publication Date
June 2016
Volume
32
Issue
5
Pages
310–316
Identifiers
DOI: 10.1089/jop.2015.0126
PMID: 26692377
Source
Medline
License
Unknown

Abstract

The use of porous PLGA scaffolds to differentiate iPSCs to retinal phenotypes is a feasible pretransplantation approach. This adds to an important knowledge base; understanding how developing retinal cells interact with polymer substrates with varying structure is a crucial component of optimizing cell therapy strategies.

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