Affordable Access

Differential Roles of Dendritic Cells in Expanding CD4 T Cells in Sepsis

Authors
  • darkwah, samuel
  • nago, nodoka
  • appiah, michael g.
  • myint, phyoe kyawe
  • kawamoto, eiji
  • shimaoka, motomu
  • park, eun jeong
Publication Date
Jul 18, 2019
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

-treated CD4 T cells expanded in a dose-dependent manner, suggesting that this cytokine acts as a key mediator of MLN DCs in promoting septic inflammation. Thus, mucosal and systemic DCs were found to be functionally different in the way CD4 T cells respond during sepsis. Our study provides a molecular basis for DC activity, which can be differential in nature depending on location, whereby it induces septic inflammation or immune-paralysis.

Report this publication

Statistics

Seen <100 times