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Differential Recruitment of Dentate Gyrus Interneuron Types by Commissural Versus Perforant Pathways.

Authors
  • Hsu, Tsan-Ting1
  • Lee, Cheng-Ta1
  • Tai, Ming-Hong2
  • Lien, Cheng-Chang3
  • 1 Institute of Neuroscience.
  • 2 Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan. , (Taiwan)
  • 3 Institute of Neuroscience Brain Research Center, National Yang-Ming University, Taipei, Taiwan. , (Taiwan)
Type
Published Article
Journal
Cerebral Cortex
Publisher
Oxford University Press
Publication Date
June 2016
Volume
26
Issue
6
Pages
2715–2727
Identifiers
DOI: 10.1093/cercor/bhv127
PMID: 26045570
Source
Medline
Keywords
License
Unknown

Abstract

Gamma-aminobutyric acidergic (GABAergic) interneurons (INs) in the dentate gyrus (DG) provide inhibitory control to granule cell (GC) activity and thus gate incoming signals to the hippocampus. However, how various IN subtypes inhibit GCs in response to different excitatory input pathways remains mostly unknown. By using electrophysiology and optogenetics, we investigated neurotransmission of the hilar commissural pathway (COM) and the medial perforant path (MPP) to the DG in acutely prepared mouse slices. We found that the short-term dynamics of excitatory COM-GC and MPP-GC synapses was similar, but that the dynamics of COM- and MPP-mediated inhibition measured in GCs was remarkably different, during theta-frequency stimulation. This resulted in the increased inhibition-excitation (I/E) ratios in single GCs for COM stimulation, but decreased I/E ratios for MPP stimulation. Further analysis of pathway-specific responses in identified INs revealed that basket cell-like INs, total molecular layer- and molecular layer-like cells, received greater excitation and were more reliably recruited by the COM than by the MPP inputs. In contrast, hilar perforant path-associated and hilar commissural-associational pathway-related-like cells were minimally activated by both inputs. These results demonstrate that distinct IN subtypes are preferentially recruited by different inputs to the DG, and reveal their relative contributions in COM-mediated feedforward inhibition.

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