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Differential predictive factors for cardiovascular events in patients with or without cancer history.

  • Sueta, Daisuke1, 2
  • Tabata, Noriaki1, 2
  • Ikeda, Satoshi3
  • Saito, Yuichi4
  • Ozaki, Kazuyuki5
  • Sakata, Kenji6
  • Matsumura, Takeshi2, 7
  • Yamamoto-Ibusuki, Mutsuko8
  • Murakami, Yoji9
  • Jodai, Takayuki10
  • Fukushima, Satoshi11
  • Yoshida, Naoya12, 13
  • Kamba, Tomomi9
  • Araki, Eiichi2, 7
  • Iwase, Hirotaka8
  • Fujii, Kazuhiko10
  • Ihn, Hironobu11
  • Kobayashi, Yoshio4
  • Minamino, Tohru5
  • Yamagishi, Masakazu6
  • And 4 more
  • 1 Department of Cardiovascular Medicine, Graduate School of Medical Sciences.
  • 2 Center for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto.
  • 3 Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki.
  • 4 Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba.
  • 5 Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata.
  • 6 Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa.
  • 7 Department of Metabolic Medicine, Faculty of Life Sciences.
  • 8 Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences.
  • 9 Department of Urology, Faculty of Life Sciences.
  • 10 Department of Respiratory Medicine, Graduate School of Medical Sciences.
  • 11 Department of Dermatology and Plastic Surgery, Faculty of Life Sciences.
  • 12 Department of Gastroenterological Surgery, Graduate School of Medical Sciences.
  • 13 Division of Translational Research and Advanced Treatment Against Gastrointestinal Cancer.
  • 14 Community, Family, and General Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. , (Japan)
Published Article
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Nov 01, 2019
DOI: 10.1097/MD.0000000000017602
PMID: 31689764


Although attention has been paid to the relationship between malignant diseases and cardiovascular diseases, few data have been reported. Moreover, there have also been few reports in which the preventive factors were examined in patients with or without malignant disease histories requiring percutaneous coronary intervention (PCI).This was a retrospective, single-center, observational study. A total of 1003 post-PCI patients were divided into a malignant group, with current or past malignant disease, and a nonmalignant group. The primary endpoint was a composite of cardiovascular death, nonfatal myocardial infarction, stroke, revascularization, and admission due to heart failure within 5 years of PCI. Kaplan-Meier analysis showed a significantly higher probability of the primary endpoint in the malignant group (P = .002). Multivariable Cox hazard analyses showed that in patients without a history of malignant, body mass index (BMI) and the presence of dyslipidemia were independent and significant negative predictors of the primary endpoint (BMI: hazard ratio [HR] 0.73, 95% confidence interval [CI] 0.53-0.99, P = .041; prevalence of dyslipidemia: HR 0.72, 95% CI 0.52-0.99, P = .048), and the presence of multi-vessel disease (MVD) and the prevalence of peripheral artery disease (PAD) were independent and significant positive predictors of the primary endpoint (prevalence of MVD: HR 1.68, 95% CI 1.18-2.40, P = .004; prevalence of PAD: HR 1.51, 95% CI 1.03-2.21, P = .034). In patients with histories of malignancy, no significant independent predictive factors were identified.Patients undergoing PCI with malignancy had significantly higher rates of adverse cardiovascular events but might not have the conventional prognostic factors.

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