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Differential patterns of spinal cord and brain atrophy in NMO and MS.

Authors
  • Liu, Yaou
  • Wang, Jinhui
  • Daams, Marita
  • Weiler, Florian
  • Hahn, Horst K
  • Duan, Yunyun
  • Huang, Jing
  • Ren, Zhuoqiong
  • Ye, Jing
  • Dong, Huiqing
  • Vrenken, Hugo
  • Wattjes, Mike P
  • Shi, Fu-Dong
  • Li, Kuncheng
  • Barkhof, Frederik
Type
Published Article
Journal
Neurology
Publisher
Ovid Technologies (Wolters Kluwer) - American Academy of Neurology
Publication Date
Apr 07, 2015
Volume
84
Issue
14
Pages
1465–1472
Identifiers
DOI: 10.1212/WNL.0000000000001441
PMID: 25762714
Source
Medline
License
Unknown

Abstract

NMO showed predominately spinal cord atrophy with mild brain atrophy, while MS demonstrated more brain atrophy, especially in the gray matter. MUCCA is the main MRI-derived parameter for explaining clinical disability in NMO and MS, and may serve as a potential biomarker for further clinical trials, especially in NMO.

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