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Differential modulation of cyclin gene expression by MYC.

Authors
  • Jansen-Dürr, P
  • Meichle, A
  • Steiner, P
  • Pagano, M
  • Finke, K
  • Botz, J
  • Wessbecher, J
  • Draetta, G
  • Eilers, M
Type
Published Article
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publication Date
Apr 15, 1993
Volume
90
Issue
8
Pages
3685–3689
Identifiers
PMID: 8386381
Source
Medline
License
Unknown

Abstract

We have investigated the effects of deregulated expression of the human c-MYC protooncogene on cyclin gene expression and on the transcription factor E2F. We found that constitutive expression of MYC or activation of conditional MycER chimeras led to higher levels of cyclin A and cyclin E mRNA. Activation of cyclin A expression by MYC led to a growth factor-independent association of cyclin A and cdk2 with the transcription factor E2F and correlated with an increase in E2F transcriptional activity. In contrast, expression of the G1 phase cyclin D1 was strongly reduced in MYC-transformed cells. In synchronized cells, repression of cyclin D1 by MYC occurred very early in the G1 phase of the cell cycle.

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