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Differential Metabolomic Signatures in Patients with Weight Regain and Sustained Weight Loss After Gastric Bypass Surgery: A Pilot Study.

Authors
  • Abidi, Wasif1, 2
  • Nestoridi, Eirini2, 3
  • Feldman, Henry4
  • Stefater, Margaret2, 3
  • Clish, Clary5
  • Thompson, Christopher C6, 7
  • Stylopoulos, Nicholas8, 9, 10
  • 1 Developmental Endoscopy Laboratory, Gastroenterology Division, Brigham and Women's Hospital, 75 Francis St, Thorn 1404, Boston, MA, 02115, USA.
  • 2 Harvard Medical School, Boston, MA, USA.
  • 3 Division of Endocrinology, CLS16066, Center for Basic and Translational Obesity Research, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA.
  • 4 Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, MA, USA.
  • 5 Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • 6 Developmental Endoscopy Laboratory, Gastroenterology Division, Brigham and Women's Hospital, 75 Francis St, Thorn 1404, Boston, MA, 02115, USA. [email protected]
  • 7 Harvard Medical School, Boston, MA, USA. [email protected]
  • 8 Harvard Medical School, Boston, MA, USA. [email protected]
  • 9 Division of Endocrinology, CLS16066, Center for Basic and Translational Obesity Research, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA. [email protected]
  • 10 Broad Institute of MIT and Harvard, Cambridge, MA, USA. [email protected]
Type
Published Article
Journal
Digestive Diseases and Sciences
Publisher
Springer-Verlag
Publication Date
Apr 01, 2020
Volume
65
Issue
4
Pages
1144–1154
Identifiers
DOI: 10.1007/s10620-019-05714-3
PMID: 31385097
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

While Roux-en-Y gastric bypass (RYGB) is one of the most effective and durable treatment options for obesity and its comorbidities, it is complicated by long-term weight regain in over 20% of patients. We sought to determine the metabolite signatures of serum samples of patients with weight regain (RYGB-WR) after RYGB and features distinguishing these patients from patients with sustained weight loss (RYGB-SWL). We prospectively analyzed serum samples from 21 RYGB-WR patients, 14 RYGB-SWL patients, and 11 unoperated controls. The main outcome measure was their serum metabolite profile. Weight regain after RYGB was associated with a unique serum metabolomic fingerprint. Most of the statistically different metabolites were involved in amino acid metabolism, one-carbon metabolism, and related nucleotide metabolism. A principal component analysis identified groups of metabolites that correlate with weight regain. Specifically, weight regain was associated with lower serum levels of metabolites related to the serine, glycine and threonine pathway, phenylalanine metabolism, tricyclic acid cycle, alanine and glutamate metabolism, and higher levels of other amino acids. Weight regain after RYGB is associated with unique serum metabolite signatures. Metabolite profiling may eventually help us to identify markers that could differentiate the patients who will regain weight versus those who will likely sustain weight loss.

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