Affordable Access

Differential inhibitory/stimulatory modulation of spinal CCK release by mu and delta opioid agonists, and selective blockade of mu-dependent inhibition by kappa receptor stimulation.

Authors
  • Benoliel, J J
  • Bourgoin, S
  • Mauborgne, A
  • Legrand, J C
  • Hamon, M
  • Cesselin, F
Type
Published Article
Journal
Neuroscience Letters
Publisher
Elsevier
Publication Date
Apr 01, 1991
Volume
124
Issue
2
Pages
204–207
Identifiers
PMID: 1648690
Source
Medline
License
Unknown

Abstract

Opioid-cholecystokinin (CCK) interactions at the spinal level were investigated by looking for possible modulations by various opioid agonists of the release of cholecystokinin-like material (CCKLM) from slices of the dorsal zone of the rat lumbar enlargement. K(+)-evoked CCKLM overflow was reduced by 0.1-10 microM of the mu agonist DAGO or 10 nM to 3 microM of the delta agonist DTLET. By contrast, at a higer concentration (10 microM), the latter drug as well as morphine enhanced CCKLM overflow. Although inactive alone, the kappa opioid agonist U 50488 H (1 microM) prevented the inhibitory effect of DAGO without affecting that of DTLET. These data suggest that an opioid acting through the stimulation of mu, delta and kappa receptors (such as morphine) should produce a net increase in the spinal release of CCK.

Report this publication

Statistics

Seen <100 times