Differential gene and protein expression in primary breast malignancies and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis.
- Authors
- Type
- Published Article
- Journal
- Cancer
- Publication Date
- Mar 15, 2004
- Volume
- 100
- Issue
- 6
- Pages
- 1110–1122
- Identifiers
- PMID: 15022276
- Source
- Medline
- License
- Unknown
Abstract
The results of the current study suggest that extracellular matrix protein expression and nuclear gene expression are associated via a negative-feedback regulatory mechanism. Therefore, gene expression profiling and tissue array validation should be combined to elucidate molecular events associated with the metastatic process.