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Differential gene and protein expression in primary breast malignancies and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis.

Authors
  • Hao, Xishan
  • Sun, Baocun
  • Hu, Limei
  • Lähdesmäki, Harri
  • Dunmire, Valerie
  • Feng, Yumei
  • Zhang, Shi-Wu
  • Wang, Huamin
  • Wu, Chunlei
  • Wang, Hua
  • Fuller, Gregory N
  • Symmans, W Fraser
  • Shmulevich, Ilya
  • Zhang, Wei
Type
Published Article
Journal
Cancer
Publication Date
Mar 15, 2004
Volume
100
Issue
6
Pages
1110–1122
Identifiers
PMID: 15022276
Source
Medline
License
Unknown

Abstract

The results of the current study suggest that extracellular matrix protein expression and nuclear gene expression are associated via a negative-feedback regulatory mechanism. Therefore, gene expression profiling and tissue array validation should be combined to elucidate molecular events associated with the metastatic process.

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