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Differential gene expression profile reveals deregulation of pregnancy specific beta1 glycoprotein 9 early during colorectal carcinogenesis.

Authors
  • Salahshor, Sima
  • Goncalves, Jason
  • Chetty, Runjan
  • Gallinger, Steven
  • Woodgett, James R
Type
Published Article
Journal
BMC Cancer
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2005
Volume
5
Pages
66–66
Identifiers
PMID: 15982419
Source
Medline
License
Unknown

Abstract

Detection of PSG9 expression in adenomas, and at higher levels in FAP cases, indicates that germline APC mutations and defects in Wnt signalling modulate PSG9 expression. Since PSG9 is not found in the non-pregnant adult except in association with cancer, and it appears to be an early molecular event associated with colorectal cancer monitoring of its expression may be useful as a biomarker for the early detection of this disease.

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