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Differential expression of an inwardly rectifying chloride conductance in rat brain neurons: a potential mechanism for cell-specific modulation of postsynaptic inhibition.

Authors
  • Smith, R L
  • Clayton, G H
  • Wilcox, C L
  • Escudero, K W
  • Staley, K J
Type
Published Article
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Publication Date
May 01, 1995
Volume
15
Issue
5 Pt 2
Pages
4057–4067
Identifiers
PMID: 7751965
Source
Medline
License
Unknown

Abstract

A voltage-sensitive inwardly rectifying chloride (Cl-) conductance (GCl(V) is present in hippocampal pyramidal but not dentate gyrus neurons and has a significant role in modulation of neuronal inhibition by GABA. GCl(V) has the same activation properties as the cloned and expressed Cl- channel CIC-2. In brain, CIC-2 was detected selectively in neurons, and in hippocampus was detected in the same populations of neurons that demonstrate GCl(V). CIC-2 mRNA expression varied widely in different neuronal populations in brain but was greatest in pyramidal and other large neurons and least in interneurons. The observed differential expression of CIC-2 provides a potential molecular basis for the paradoxical excitation produced by GABAA receptor activation in selected neuronal populations.

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