Affordable Access

Differential effects of sex hormones and phytoestrogens on peak and steady state contractions in isolated rabbit detrusor.

Authors
  • Ratz, P H
  • McCammon, K A
  • Altstatt, D
  • Blackmore, P F
  • Shenfeld, O Z
  • Schlossberg, S M
Type
Published Article
Journal
The Journal of Urology
Publisher
Elsevier
Publication Date
Nov 01, 1999
Volume
162
Issue
5
Pages
1821–1828
Identifiers
PMID: 10524942
Source
Medline
License
Unknown

Abstract

Our data support the hypothesis that 17beta-estradiol, ethinyl estradiol, DES, tamoxifen and genistein may relax detrusor contractions by inhibition of both VOCCs and non-VOCCs. Moreover, our data show that genistein, a dietary phytoestrogen with tyrosine kinase inhibitory activity, selectively reduced alpha,beta-MeATP-induced peak and BE-induced steady-state contractions, sparing the maximum response to BE. Lastly, the inactive isomer, 17alpha-estradiol, inhibited both BE- and alpha,beta-MeATP-induced contractions. These data suggest that certain dietary phytoestrogens (for example, genistein) or sex steroids, especially those with weak activity at the nuclear steroid site (for example, 17alpha-estradiol), or tamoxifen may prove therapeutically useful in treating overactive bladder caused by elevated muscarinic and purinergic receptor activation.

Report this publication

Statistics

Seen <100 times