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Differential effects of secukinumab vs. ustekinumab for treatment of psoriasis on quality of life, work productivity and activity impairment: a structural equation modelling analysis.

Authors
  • Stull, D E1
  • Griffiths, C E M2
  • Gilloteau, I3
  • Zhao, Y4
  • Guana, A5
  • Finlay, A Y6
  • Sherif, B1
  • Houghton, K1
  • Puig, L7
  • 1 RTI Health Solutions, Research Triangle Park, NC, U.S.A.
  • 2 Dermatology Centre, Salford Royal Hospital, University of Manchester, Manchester Academic Health Science Centre, The Dermatology Centre, Salford Royal NHS Foundation Trust, Barnes Building, Manchester, M6 8HD, U.K.
  • 3 Novartis Pharma AG, Basel, Switzerland. , (Switzerland)
  • 4 Sun Pharma, Cranbury, NJ, U.S.A.
  • 5 Novartis Pharmaceuticals Corporation, East Hanover, NJ, U.S.A.
  • 6 Department of Dermatology, Cardiff University School of Medicine, Cardiff, U.K.
  • 7 Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Mas Casanovas 90, Block A, 5th floor, Module 3, 08041, Barcelona, Spain. , (Spain)
Type
Published Article
Journal
British Journal of Dermatology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Jun 01, 2018
Volume
178
Issue
6
Pages
1297–1307
Identifiers
DOI: 10.1111/bjd.16366
PMID: 29355896
Source
Medline
Language
English
License
Unknown

Abstract

The appearance and lifelong, chronic nature of psoriasis result in considerable burden to patients, such as sleep impairment, depressive symptoms, negative self-esteem and reduced work productivity. To examine direct and indirect (mediated) effects of secukinumab vs. ustekinumab on quality of life, work productivity and activity impairment based on psoriasis severity and symptoms. Analyses were based on data from the CLEAR study. Structural equation modelling examined the effects of secukinumab vs. ustekinumab on the Dermatology Life Quality Index (DLQI) and on the Work Productivity and Activity Impairment (WPAI) questionnaire using Psoriasis Area and Severity Index (PASI) severity and symptoms (pain, itching and scaling) as potential mediators. Analyses were conducted primarily for patients achieving a PASI 90 response (90% or greater reduction in PASI from baseline) at week 16 (repeated at week 52) and for PASI 50, 75 and 100. Results at weeks 16 and 52 showed that the effect of treatment on change in DLQI score was mediated by the PASI 90 response and by improvements in itching, pain, and scaling. Achieving any PASI response as early as week 16 directly resulted in significantly better WPAI scores. At week 52, both PASI response and improvement in scaling directly resulted in significantly better WPAI scores. Pain, itching and scaling were correlated (r = 0·51-0·68); improvement in any of these had a significant effect (directly or indirectly) on WPAI. All results favoured secukinumab over ustekinumab. The results underscore the important role of both PASI response and reduction in symptoms on improvements in health-related quality of life and work and daily activity in favour of secukinumab vs. ustekinumab. © 2018 British Association of Dermatologists.

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