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Differential effects of nebivolol and metoprolol on arterial stiffness, circulating progenitor cells, and oxidative stress.

Authors
  • Hayek, Salim S1
  • Poole, Joseph C1
  • Neuman, Robert1
  • Morris, Alanna A1
  • Khayata, Mohamed1
  • Kavtaradze, Nino1
  • Topel, Matthew L1
  • Binongo, Jose G2
  • Li, Qunna2
  • Jones, Dean P1
  • Waller, Edmund K1
  • Quyyumi, Arshed A3
  • 1 Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA, USA.
  • 2 Department of Epidemiology, Rollins School of Public Health, Atlanta, GA, USA.
  • 3 Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: [email protected]
Type
Published Article
Journal
Journal of the American Society of Hypertension : JASH
Publication Date
Mar 01, 2015
Volume
9
Issue
3
Pages
206–213
Identifiers
DOI: 10.1016/j.jash.2014.12.013
PMID: 25681236
Source
Medline
Keywords
License
Unknown

Abstract

Unlike traditional beta receptor antagonists, nebivolol activates nitric oxide. We hypothesized that therapy with nebivolol compared with metoprolol would improve arterial stiffness, increase levels of circulating progenitor cells (PC), and decrease oxidative stress (OS). In a randomized, double-blind, cross-over study, 30 hypertensive subjects received either once daily nebivolol or metoprolol succinate for 3 months each. Pulse wave velocity and augmentation index were measured using tonometry. Flow cytometry was used to measure circulating PC. OS was measured as plasma aminothiols. Measurements were performed at baseline, and repeated at 3 and 6 months. No significant differences were present between the levels of OS, arterial stiffness, and PC numbers during treatment with metoprolol compared with nebivolol. In subgroup analyses of beta-blocker naïve subjects (n = 19), nebivolol reduced pulse wave velocity significantly compared with metoprolol (-1.4 ± 1.9 vs. -0.1 ± 2.2; P = .005). Both nebivolol and metoprolol increased circulating levels of CD34+/CD133 + PC similarly (P = .05), suggesting improved regenerative capacity.

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