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Differential Effects of HOXB4 and NUP98-HOXA10hd on Hematopoietic Repopulating Cells in a Nonhuman Primate Model

Authors
  • Korashon L. Watts
  • Xiaobing Zhang
  • Brian C. Beard
  • Sum Ying Chiu
  • Grant D. Trobridge
  • R. Keith Humphries
  • Hans-Peter Kiem
Journal
Human Gene Therapy
Publisher
Mary Ann Liebert
Publication Date
Jul 25, 2011
Volume
22
Issue
12
Identifiers
DOI: 10.1089/hum.2011.100
Keywords

Abstract

Watts and colleagues compare the effects of HOXB4 and NUP98-HOXA10hd on the expansion and engraftment of CD34+ cells. A competitive repopulation assay using CD34+ cells modified with gammaretroviral vectors expressing HOXB4YFP or NA10hdGFP was performed in pigtailed macaques. HOXB4YFP contributed more to early hematopoiesis whereas NA10hdGFP had a more significant impact at later stages.

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