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Differential effects of fentanyl and morphine on intracellular Ca2+ transients and contraction in rat ventricular myocytes.

Authors
  • Kanaya, N
  • Zakhary, D R
  • Murray, P A
  • Damron, D S
Type
Published Article
Journal
Anesthesiology
Publication Date
Dec 01, 1998
Volume
89
Issue
6
Pages
1532–1542
Identifiers
PMID: 9856730
Source
Medline
License
Unknown

Abstract

Fentanyl and morphine directly depress cardiac excitation-contraction coupling at the cellular level. Fentanyl depresses myocardial contractility by decreasing the availability of intracellular Ca2+ and myofilament Ca2+ sensitivity. In contrast, morphine depresses myocardial contractility primarily by decreasing myofilament Ca2+ sensitivity.

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