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Differential effectiveness of complement fixed by IgG and IgM antibodies in the cytolysis of dog kidney tissue culture cells

Authors
  • K. W. Sell
  • R. L. Spooner
Publication Date
Dec 01, 1966
Source
PMC
Keywords
License
Unknown

Abstract

Sensitizing and complement fixing properties of IgG (7S) and IgM (19S) rabbit anti-horse kidney (Forssman) antibodies have been studied. Agglutination, indirect antiglobulin and mixed antiglobulin techniques were used to determine the extent of antibody sensitization of sheep red cells and dog kidney tissue culture cells. Immune adherence and mixed conglutination were used to demonstrate the presence of sites of complement fixation on these sensitized cells. The relationship between the presence of fixed complement and the subsequent immune lysis of the test cells was examined.

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