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Differential effect of high-fat, high-sucrose and combined high-fat/high-sucrose diets consumption on fat accumulation, serum leptin and cardiac hypertrophy in rats.

Authors
  • Gómez-Crisóstomo, N P1
  • De la Cruz-Hernández, E N1
  • Méndez Méndez, E R1
  • Hernández-Landero, M F1
  • Camacho Liévano, J U1
  • Martínez-Abundis, E1
  • 1 Laboratory of Research in Metabolic and Infectious Diseases, Multidisciplinary Academic Division of Comalcalco, Juarez Autonomous University of Tabasco, Tabasco, México.
Type
Published Article
Journal
Archives of physiology and biochemistry
Publication Date
Jul 01, 2020
Volume
126
Issue
3
Pages
258–263
Identifiers
DOI: 10.1080/13813455.2018.1517181
PMID: 30270670
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The consumption of high calorie-content diets is the first cause of obesity, probably the main health issue worldwide; however, the experimental evidences for evaluating the differential metabolic modifications of high-sucrose or high-fat diets are scare. We evaluated the metabolic outcomes of the obesity induced by the chronic consumption of high-sucrose (HS), high-fat (HF) or combined diets (HSHF), among the effect on the development of cardiac hypertrophy in Wistar rats. Rats from the HS, HF, and HSHS groups developed moderate obesity. Only the HS group showed increased triglycerides levels after four months. Increased leptin levels were observed in HS and HF groups without changes on cardiac hypertrophy; on the opposing, HSHF group presented hypertrophy without the changes in serum leptin. The three experimental groups showed a decreased expression of leptin receptors ObR-b. In our results, the kind of diet for the induction of obesity is relevant for the outcome of the pathological profile.

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