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Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer’s Disease

  • Boccardi, Virginia1
  • Westman, Eric2
  • Pelini, Luca1
  • Lindberg, Olof2
  • Muehlboeck, J-Sebastian2
  • Simmons, Andrew3
  • Tarducci, Roberto4
  • Floridi, Piero5
  • Chiarini, Pietro5
  • Soininen, Hilkka6
  • Kloszewska, Iwona7
  • Tsolaki, Magda8
  • Vellas, Bruno9
  • Spenger, Christian10
  • Wahlund, Lars-Olof2
  • Lovestone, Simon11
  • Mecocci, Patrizia1
  • 1 Department of Medicine, Institute of Gerontology and Geriatrics, University of Perugia, Perugia , (Italy)
  • 2 Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm , (Sweden)
  • 3 Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London , (United Kingdom)
  • 4 Division of Medical Physics, Perugia University Hospital, Perugia , (Italy)
  • 5 Division of Neuroradiology, Perugia University Hospital, Perugia , (Italy)
  • 6 Department of Neurology, University of Eastern Finland – Kuopio University Hospital, Kuopio , (Finland)
  • 7 Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Łódź, Łódź , (Poland)
  • 8 3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki , (Greece)
  • 9 University of Toulouse, INSERM 1027, Gérontopôle, Toulouse , (France)
  • 10 Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm , (Sweden)
  • 11 Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford , (United Kingdom)
Published Article
Frontiers in Aging Neuroscience
Frontiers Media SA
Publication Date
Jan 17, 2019
DOI: 10.3389/fnagi.2018.00439
  • Neuroscience
  • Original Research


Background/Aims: We aimed to assess the association between in volumetric measures of hippocampal sub-regions – in healthy older controls (HC), subjects with mild cognitive impairment (MCI) and AD- with circulating levels of IL-4. Methods: From AddNeuroMed Project 113 HC, 101 stable MCI (sMCI), 22 converter MCI (cMCI) and 119 AD were included. Hippocampal subfield volumes were analyzed using Freesurfer 6.0.0 on high-resolution sagittal 3D-T1W MP-RAGE acquisitions. Plasmatic IL-4 was measured using ELISA assay. Results: IL-4 was found to be (a) positively associate with left subiculum volume (β = 0.226, p = 0.037) in sMCI and (b) negatively associate with left subiculum volume (β = -0.253, p = 0.011) and left presubiculum volume (β = -0.257, p = 0.011) in AD. Conclusion: Our results indicate a potential neuroprotective effect of IL-4 on the areas of the hippocampus more vulnerable to aging and neurodegeneration.

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