Affordable Access

deepdyve-link
Publisher Website

Differential antigen presentation kinetics of CD8+ T-cell epitopes derived from the same viral protein.

Authors
  • Sacha, Jonah B
  • Reynolds, Matthew R
  • Buechler, Matthew B
  • Chung, Chungwon
  • Jonas, Anna K
  • Wallace, Lyle T
  • Weiler, Andrea M
  • Lee, Wonhee
  • Piaskowski, Shari M
  • Soma, Taeko
  • Friedrich, Thomas C
  • Wilson, Nancy A
  • Watkins, David I
Type
Published Article
Journal
Journal of Virology
Publisher
American Society for Microbiology
Publication Date
Sep 01, 2008
Volume
82
Issue
18
Pages
9293–9298
Identifiers
DOI: 10.1128/JVI.00749-08
PMID: 18596093
Source
Medline
License
Unknown

Abstract

The kinetics of peptide presentation by major histocompatibility complex class I (MHC-I) molecules may contribute to the efficacy of CD8+ T cells. Whether all CD8+ T-cell epitopes from a protein are presented by the same MHC-I molecule with similar kinetics is unknown. Here we show that CD8+ T-cell epitopes derived from SIVmac239 Gag are presented with markedly different kinetics. We demonstrate that this discrepancy in presentation is not related to immunodominance but instead is due to differential requirements for epitope generation. These results illustrate that significant differences in presentation kinetics can exist among CD8+ T-cell epitopes derived from the same viral protein.

Report this publication

Statistics

Seen <100 times